World Journal of
Pharmaceutical and Life Sciences

FORMULATION, DEVELOPMENT AND EVALUATION OF AMOXICILLIN FAST DISSOLVING TABLETS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman, Abdulmalik Abudunia, Shada Hassan Yassin and Jalal H. Abdullah

ABSTRACT

The development of formulation and evaluation of Amoxicillin Trihydrate Fast Dissolving Tablets to improve the bioavailability of Amoxicillin Trihydrate. Amoxicillin Trihydrate is classified as a biopharmaceutics classification system (BCS) Class-I, Class-II and Class-IV Drug according to the dose. Amoxicillin is a hydrophilic drug, increase the solubility and permeability improve the bioavailability and onset of action of Amoxicillin Trihydrate has been done. The drug-excipient compatibility studies were conducted to characterize the drug Amoxicillin Trihydrate present in Fast Dissolving Tablets Delivery System FDTs. The objective of this study was to formulate Amoxicillin Fast Dissolving Tablets to ensure the release of the drug at the sites of its absorption, also to develop a patient-friendly Fast Dissolving Tablets of Amoxicillin to increase the patient’s adherence and compliance to the therapy. Amoxicillin was prepared as a Fast-Dissolving Tablets in 500mg dose. Six formulae containing Amoxicillin Trihydrate and various excipients as mannitol, and MCC as diluents, and sodium starch glycolate, croscarmellose sodium, and crospovidone as superdisintegrants in different ratios. Then, each formula was evaluated for precompression parameters, then prepared by direct compression method. Finally, the compressed tablets of each formulation were evaluated for the post compression parameters. All the formulations showed satisfactory tablet properties. Among the 12 formulations the drug release of formulation F12 was found to be 94.78% at 2 minutes. Formulation F12 was the best formulation as it showed a drug release percentage was 94.78% at 2 minutes, due to rapid disintegration and fine dispersion of particles formed after disintegration within 30 seconds.

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