World Journal of
Pharmaceutical and Life Sciences

PHYTOCHEMICAL PROFILING AND STRUCTURAL CHARACTERIZATION OF BIOACTIVE CONSTITUENTS FROM THE ETHANOLIC LEAF EXTRACT OF CORDIA MACLEODII USING HIGH-RESOLUTION LC-MS ANALYSIS

Nidhi Shukla* and Nilesh Thawarey

ABSTRACT

Background: Cordia macleodii, a critically endangered species recognized for its medicinal properties, possesses considerable ethnopharmacological significance; however, the comprehensive exploration of its phytochemical constituents remains limited. Results: The ethanolic leaf extract of Cordia macleodii underwent rigorous analysis via High-Resolution Liquid Chromatography–Mass Spectrometry (HR-LC-MS/QTOF), which facilitated the identification of an array of bioactive constituents, encompassing phenolic acids, flavonoids, fatty acid derivatives, and glycosidic compounds. These identified compounds are associated with significant pharmacological activities, which include antioxidant, anti-inflammatory, and antidiabetic properties. Conclusion: The detailed phytochemical profiling of Cordia macleodii lays a critical groundwork for subsequent functional investigations, thereby integrating traditional medicinal practices with contemporary drug discovery methodologies, while underscoring its therapeutic potential as a reservoir of plant-derived bioactive compounds. Highlights: In-depth HR-LC-MS/QTOF analysis of the ethanolic leaf extract of Cordia macleodii. Identification of phenolic acids, flavonoids, and glycosidic compounds. Prospective therapeutic applications, encompassing antioxidant, anti-inflammatory, and antidiabetic activities. Integration of traditional medicinal applications with modern phytochemical validation.

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