World Journal of
Pharmaceutical and Life Sciences

INVASIVE PULMONARY AND SINUS ASPERGILLOSIS IN A NEUTROPENIC CHILD: A CASE REPORT

Ahmed Hared Bouh*, Abdisalam Oumar Hassan, Mahdi Dahir Malow and Nouzha Dini

ABSTRACT

Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised children. It is an opportunistic infection caused by a saprophytic Aspergillus species commonly found in the environment. We report a case of invasive aspergillosis with both pulmonary and sinus involvement. The patient is a 15-year-old boy under treatment for idiopathic aplastic anemia (corticosteroids, cyclosporine, and anti-lymphocyte serum). The symptoms began two days prior to admission, with a sudden onset of high fever, dry cough, chest pain, and severe headache predominantly affecting the right side of the face. Laboratory tests revealed severe pancytopenia, a biological inflammatory syndrome, a positive blood culture for beta-lactamase-producing Klebsiella pneumoniae, and a galactomannan antigen level of 1.3 ng/mL. Thoracic and sinus CT scans showed bilateral pneumonia associated with right pansinusitis without bone destruction. Clinical, biological, and radiological findings confirmed the diagnosis of invasive pulmonary and sinus aspergillosis. Early diagnosis and treatment of this condition significantly improve both vital and functional prognosis.

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