World Journal of
Pharmaceutical and Life Sciences

FORMULATION, DEVELOPMENT AND EVALUATION OF PLICOSEPALUS ACACIA EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR CONTROLLING DIABETES

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

ABSTRACT

Diabetes is a serious health concern in many countries with high blood glucose, obesity, and multiple organ failures in late stages. Treating diabetes with effective drugs is still a challenging issue since most of the available diabetic drugs are not effective in combating diabetes, especially in secondary disease complications like obesity retinopathy, and nephropathy associated diabetes. Hence search for effective anti-diabetic medication, especially from natural sources is mandatory with no adverse side effects. The Plicosepalus acacia plant widely distributed in Yemen. The Plicosepalus acacia is plant widely distributed in Yemen, a large number of medicinal plants have been tested and found to contain active principles with curative properties against a variety of diseases. Liver protective plants contain a variety of chemical constituents like flavonoids, Phenol, Tannins, Steroids, Amino acid and Triterpene glycoside. Therefore, a large number of plants and formulations have been claimed to have anti-diabetic medication so the development of plant based diabetic drugs has been given importance in the global market. Plicosepalus acacia is commonly used in traditional medicine for a wide range of ailments including hepatoprotective activity. A Plicosepalus acacia was formulated as capsules and evaluated for organoleptic properties and other evaluation parameters. It was concluded that the formulation of Plicosepalus acacia extract medicinal herbs capsules delivery system as an advanced phytotherapy approach for controlling diabetes according to the best results of in-vitro dissolution was found to be 76.8% within 45 minutes in acid medium and were evaluated.

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