World Journal of
Pharmaceutical and Life Sciences

MOGAD-ASSOCIATED OPTIC NEURITIS IN TWO PEDIATRIC PATIENTS

Manira Moussa Ahmed*, Omar Moussa Sougueh, Nadia Echcharii, Nabila Chekhlabi and Nezha Dini

ABSTRACT

Optic neuritis (ON) in children represents a rare but serious inflammatory condition of the optic nerve, often
presenting with acute visual loss, ocular pain, and variable neurological signs. It's a diagnostic emergency. Among
the evolving spectrum of acquired demyelinating syndromes in pediatric populations, myelin oligodendrocyte
glycoprotein antibody-associated disease (MOGAD) has emerged as a distinct nosological entity, with important
diagnostic, prognostic, and therapeutic implications. Characterized by the presence of serum immunoglobulin G
(IgG) antibodies directed against the MOG protein. MOGAD is increasingly recognized as a major cause of
recurrent or bilateral optic neuritis in the pediatric age group.
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