World Journal of
Pharmaceutical and Life Sciences

HISTOPATHOLOGICAL STUDY AND EFFECT OF ETHION IN DIFFERENT TISSUES OF DANIO RERIO

Vinayan K. V. and Tijare R. V.*

ABSTRACT

Ethion an organophosphate categorized as class II hazardous chemical as per WHO classification, which acts as an acetylcholinesterase inhibitor when reaches persistently to non-target organisms like aquatic life, raises environmental concerns, the accumulation in different tissues may cause serious damage leading to organ dysfunction. The current experiment was performed to investigate the changes in histology of selected tissues induced by ethion. The Danio rerio (Zebrafish) was subjected to three sublethal doses i.e. 0.340 mg/L, 0.476 mg/L and 0.612 mg/L at four-time intervals viz. 24 hours, 48 hours, 72 hours and 96 hours for any histological changes in gills, liver and muscle tissues. The histological changes were observed for different time periods and concentrations. It was evident from the current study that ethion has impacted adversely and caused histological changes in all 3 tissues under study. The histological examination has shown progressive adverse changes in gills, liver and muscles with increased doses and exposure time when compared to control. The histological changes in gills, liver and muscles can be used as bioindicator of eco-toxicity. So, it’s imperative that there should be a judicious use of ethion and ecological concerns should be considered while use of ethion.

[Full Text Article]   [Download Certificate]