World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF POLY HERBAL ANTHELMINTIC SYRUP

K. Nagaraja*, Dr. G. Tulja Rani, G. Mounika, S. Hema Harshitha and K. Anjith Kumar

ABSTRACT

This study focuses on the formulation and evaluation of a polyherbal anthelmintic syrup incorporating extracts of Annona squamosa (custard apple), Plumeria rubra (frangipani), and Musa paradisiaca (banana). These plants are traditionally recognized for their medicinal properties, particularly their effectiveness against parasitic worm infections. The syrup was prepared using aqueous and ethanolic/methanolic extracts of the selected plants, aiming to provide a synergistic effect for enhanced anthelmintic activity. Preliminary phytochemical screening confirmed the presence of bioactive constituents such as alkaloids, tannins, saponins, and flavonoids, which are known to exhibit anthelmintic potential. In vitro studies using Pheretima posthuma (Indian earthworm) demonstrated significant paralysis and death times, indicating strong wormicidal activity. The formulated syrup was also evaluated for physicochemical parameters and stability. Results suggest that the polyherbal combination can serve as an effective and natural alternative to synthetic anthelmintic drugs with reduced side effects.

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