World Journal of
Pharmaceutical and Life Sciences

COMPARATIVE ANALYSIS OF AZATHIOPRINE AND METHOTREXATE IN RHEUMATOID ARTHRITIS: SAFETY, COMPLIANCE, EFFICACY AND COST EFFECTIVENESS

*Sarvesh Nikesh R., M. Ranjith, J. Rebekal, Rajkumar A., Dinesh P., Vasanthi C. and Gnanasekar P.

ABSTRACT

Rheumatoid arthritis is a habitual seditious condition that occurs at joints, blood vessels and bones which leads to the physical incapability and internal illness. It caused by vulnerable factors and microbial factors. The treatment for Rheumatoid arthritis is done by NSAIDs [non-steroidal anti-inflammatory medicines], DMARDs [Disease modifying anti-rheumatic medicines], glucocorticoids, natural agents- monoclonal antibody remedy. DMARDs are the agents that performs major part in repression of the condition RA. The medicines like cyclosporine, azathioprine, methotrexate, hydroxychloroquine were involved in remedy. The information is collected through colourful journals and papers of arthritis from PubMed and Google scholar. The azathioprine [AZA] and Methotrexate [MTZ] both are immunomodulatory [immunosuppressive] agents that are used in colourful bus vulnerable conditions treatment. Azathioprine is a purine analogy which intrude with protein conflation and cell proliferation and reduces RA. Methotrexate is a medicine which is of same class intrude with DHFR [di- hydro folate reductase] reduce cell proliferation, hyperactive vulnerable response and active macrophages. Still the medium is analogous, but its adverse effect, patient compliance, safety and cost factors differs. Azathioprine considered to be most patient compliable, effective, safe and cost effective as compared to methotrexate.

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