World Journal of
Pharmaceutical and Life Sciences

A PROSPECTIVE, OPEN-LABEL, SINGLE-ARM PHASE II CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SCURF HERBAL OIL IN THE MANAGEMENT OF DANDRUFF AND HAIR FALL

Sreedevi A. P.*, Anu Joy, Maneesha K. S., Reeshma C. R., Sibi Narayanan and Adithya Peethambara Panicker

ABSTRACT

Introduction: Dandruff and hair fall are common scalp conditions that impact quality of life. Scurf Herbal Oil, a topical Ayurvedic formulation combining Danthapala (Wrightia tinctoria) and Durdura (Datura metel) infused in coconut oil, has been developed by Sitaram Ayurveda. This Phase II clinical trial aimed to evaluate the efficacy and safety of Scurf Herbal Oil in managing mild to moderate dandruff and hair fall. Methodology: A prospective, open-label, single-arm Phase II clinical trial was conducted over 6 weeks with 120 adult participants. Participants applied Scurf Herbal Oil topically to the scalp. The primary outcomes were reductions in dandruff severity and hair fall, assessed through clinical evaluations, ie Dandruff Severity Index scoring. Results: The trial demonstrated a 69% reduction in dandruff severity and a 67% decrease in hair fall by the end of 6 weeks. Participant satisfaction was high, with 87% reporting visible improvements and 90% expressing interest in continued use. No serious adverse events were reported, indicating an excellent safety profile. Discussion: The significant reductions in dandruff and hair fall suggest that Scurf Herbal Oil is an effective topical treatment for mild to moderate scalp conditions. The high participant satisfaction and absence of serious adverse events further support its potential as a safe, user-friendly alternative to conventional treatments. The herbal formulation’s natural ingredients may contribute to its efficacy and tolerability. Conclusion: Scurf Herbal Oil is a promising natural alternative for managing dandruff and hair fall, with demonstrated efficacy and safety in this Phase II trial.

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