World Journal of
Pharmaceutical and Life Sciences

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW DRUG CANDIDATE AS A POTENTIAL MEMORY ENHANCER

Ishwari R. Chaudhari* (PhD Scholar), Dr. Deepak S. Mohale (PhD Supervisor) and Prof. Dr. Anil Chandewar (Principle)

ABSTRACT

? Introduction: Alzheimer's disease (AD) is a neurodegenerative disease of the brain associated with decrease of cognitive function, memory impairment, and behavioral changes. More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The duration of the disease can vary between 5 years and 20 years. 5-hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter in the modulation of the cognitive, behavioral and psychological functions in animals and humans. Among the fourteen subtypes of 5-HT receptor, 5-HT1A receptor has been extensively studied. An azapirone derivative with strong and selective agonist effect on 5-HT1A receptor, has been used for the treatment of anxiety disorders especially generalized Alzheimer's disease for decades. With the advances in studies of the pathogenic mechanisms in AD.The target of new AD drug development has been directed to modifying the pathology.
? Aim & Objective: To design and synthesize the new chemical entity as a new class of azapirone derivative.
? Method: Generated virtual library of compound having structural similarity with available entity then sort out promising compound from the generated library by virtual screening then select specific compounds by performed molecular docking of selected compounds form the library and see the desired interaction then performed molecular dynamics of specific molecules. Sorted final lead molecules showing desired properties and synthesized and characterization of final lead molecule and evaluated the Alzheimer activity.
? Results: azapirone derivative compounds shows significant effect on Alzheimer's disease.

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