World Journal of
Pharmaceutical and Life Sciences

PHARMACOGNOSTIC PHYTOCHEMICAL STANDARDIZATION AND INVITRO TESTING OF ANTI_UROLITHIATIC AND NEPHROPROTECTIVE ACTIVITY IN EXCOECARIA AGALLOCHA LEAVES

*Vijayakumar S., Thilagam E. and Senthil Kumar N.

ABSTRACT

The Pharmacognostic, phytochemical and pharmacological studies of the leaves of Excoecaria agallocha L. Pharmacognostical Studies, Phytochemical screening of the extract, Identification of quercetin in hydroalcoholic extract of Excoecaria agallocha leaves (HAEEA) by HPTLC method. In-silico Molecular docking studies to check the effect of anti-oxidant potential of the extract by using DPPH (2-Diphenyl 1-2 picrylhydrazyl) assay and Nitric Oxide Scavenging Assay. anti-urolithiatic activity of hydroalcoholic extract of Excoecaria agallocha (HAEEA) by nucleation assay, nephroprotective activity of hydroalcoholic extract of Excoecaria agallocha (HAEEA) against cisplatin induced nephrotoxicity in In-vitro Vero cell lines. Studies on the morphology and micromorphology of medicinal plants have always been accorded due credence in pharmacognosy. It is essential to identify the botanical identity of the plants before analyzing their medicinal properties. There is a possibility that a researcher can discover a new compound in a plant or that the plant has many useful pharmacological properties. Hydroalcoholic extract of Excoecaria agallocha leaves was very effective in the management of urolithiasis and cisplatin induced nephrotoxicity, which may be due to the presence of quercetin. The presence of quercetin in HAEEA is likely responsible for these effects, as quercetin has previously been reported to play a crucial role in kidney function. Utilizing computer aided drug design, quercetin could serve as a lead molecule for developing new synthetic drugs to treat kidney-diseased patients.

[Full Text Article]   [Download Certificate]