World Journal of
Pharmaceutical and Life Sciences

FORMULATION, DEVELOPMENT & EVALUATION OF DISPERSIBLE TABLET OF ETHIONAMIDE

Abdur Rafe* and Dr. A. Balasubramaniam

ABSTRACT

The objective of this study was to develop an optimized stable dispersible tablet of the Ethionamide.
Ethionamide selected for the study acts by inhibition of mycolic acid synthesis by inhibition of enoyl reductase enzyme. The dispersible tablets were prepared by different binders, disintegrant and flavours finally optimized with a tablet weight of 270 mg. The Ethionamide was evaluated for pre formulation studies like DSC and by physical observation of binary mixture of drug and excipients. DSC study revealed that melting point of the drug was 161.70 C DSC thermograms and physical observation shown that both Ethionamide and were used in the formulation were compatible and have no significant change in the binary mixture of drug and excipients. The pre compressional and post compressional studies were carried out on dispersible tablets. The values were within the acceptance limit. The flow properties of the drug were improved by granulation. The post compressional parameters like Weight variation, Hardness, Thickness, Disintegration time, Fineness of dispersion, in -vitro dissolution study were performed and they found to be satisfactory. In order to evaluate the stability, the final optimized formulation was charged at long term and accelerated conditions of temperature and humidity as per ICH guidelines (25?C/60% RH and 40?C/75% RH) and the exposed samples were evaluated for physical parameters and in-vitro dissolution study.

[Full Text Article]   [Download Certificate]