World Journal of
Pharmaceutical and Life Sciences

REVIEW ON SOLID DISPERSION AND THEIR FORMULATION TECHNIQUES

Vankudavath Manthru Naik*, Chennu M M Prasada Rao

ABSTRACT

Solid dispersions have garnered considerable schol
arly attention as a proficient strategy for augmenting the
dissolution rate and, consequently, the bioavailability of various weakly water soluble pharmaceuticals. The
formulation of solid dispersions comprising weakly water soluble drugs in conjunction wi th water soluble carriers
has mitigated the prevalence of associated challenges and has enhanced dissolution rates. Solid dispersion
represents a solubilization methodology that predominantly focuses on drug polymer binary systems, wherein the
dispersion o f the drug and its stabilization serve as pivotal elements in the formulation development process. As
such, this methodology is acknowledged as an advantageous approach for ameliorating the dissolution
characteristics of poorly soluble pharmacological agen ts. In recent years, a substantial body of knowledge has been
amassed regarding solid dispersions; nevertheless, their practical application within the commercial sector remains
constrained. This review article emphasizes critical aspects such as solubilit y, the Biopharmaceutical Classification
System (BCS) classification, and the selection of carriers. Furthermore, this article delineates various preparation
methodologies for solid dispersions and compiles recent technological advancements in this arena. T he distinct
categories of solid dispersions are highlighted based on the utilized carrier and the molecular configurations
involved. Additionally, it encapsulates the underlying mechanisms, the preparatory techniques for solid dispersions,
and the commerci ally available pharmaceuticals that utilize solid dispersion methodologies.

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