World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF MOUTH- DISSOLVING TABLETS OF LINAGLIPTIN PREPARED BY DIRECT COMPRESSION METHOD

Kalyani Kondapalli*, Hari Bhavani and Durga Laxmi Priya

ABSTRACT

Linagliptin belongs to the class of DPP-4 inhibitors. It is mainly used as an anti-diabetic drug for the treatment of type 2 diabetes. But the main drawback of the drug is its longer half-life of about 8.6-23.9 hours. Thereby, the mouth dissolving tablets are introduced to order to achieve the immediate therapeutic action. The main aim of the study is the formulation and evaluation of mouth dissolving tablets of linagliptin by the direct compression method. This technique involves the use of super disintegrants like sodium starch glycolate and croscarmellose. MDTs prepared were evaluated for the pre- and post-compression studies. The in vitro dissolution studies explain that the increase in the concentration of super disintegrant in the formulation reduces the disintegration time and improves the dissolution rate of the drug. The formulations with sodium starch glycolate show greater action compared to formulations with croscarmellose. The evaluation studies conclude that the disintegration time is reduced to seconds. The study concludes that the formulation of mouth dissolving tablets using super disintegrants like sodium starch glycolate and croscarmellose is the better technique to ensure faster drug release and patient compliance.

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