World Journal of
Pharmaceutical and Life Sciences

CONCEPTUAL STUDY ON EFFICACY OF PALASHA KSHARA IN MANAGEMENT OF NON ALCOHOLIC FATTY LIVER DISEASE

Shivani Suresh Karanth* and Srinivas Masalekar

ABSTRACT

Increasingly sedentary lifestyles and changing dietary patterns mean that the prevalence of obesity and insulin resistance has increased worldwide and fat accumulation in the liver is a common finding during abdominal imaging studies and on liver biopsy. In the absence of high alcohol consumption (typically, a threshold of <20 g/day for women and <30 g/day for men is adopted), this is called Non-alcoholic fatty liver disease (NAFLD). NAFLD is a wide spectrum of diseases characterized by fatty infiltration of the liver, simple steatosis, steatohepatitis, advanced fibrosis and cirrhosis.[1] NAFLD can be correlated to Kaphaja Yakrutodara. Kapha Medo Dushti occurs in the initial stage of NAFLD. This condition progresses to Non-Alcoholic Steato Hepatitis (NASH) due to inflammatory changes when Pitta dosha gets involved in the pathogenesis. Further fibrosis occurs which may lead to Cirrhosis when Vata dosha is involved. The management is breakdown of pathological factors like Agnivaigunya, Srotorodha and Kaphamedodushti. Restriction of consumption of fatty food, doing physical exercise and weight reduction form the first line of treatment. No agents specific for treatment of NAFLD is available. Since NAFLD is a multifactorial disease, single target based therapy has limited implications.Through the proper administration of Ayurvedic medications along with lifestyle modifications, progression of the disease and further complications can be prevented to a great extent. Kshara prayoga is indicated in udara. Palasha is considered as kshara sreshta.[2] Palasha paneeya kshara prayoga is mentioned by acharya susrutha in management of Yakriddalyudara.[3] Hence this study has been taken up to understand the role of Palasha paneeya kshara in management of NAFLD.

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