Abstract
VON WILLBRAND DISEASE: CONTRIBUTIONS AND CHALLENGES OF BIOLOGICAL DIAGNOSIS
Dr. H. Alaoui Mdarhri*, Dr. L. Ennefah, Pr. J. El Bakkouri and Pr. A. Belmekki
ABSTRACT
Willebrand disease is the most common constitutional bleeding disorder, affecting approximately 0.6 to 1.3% of the population. It is characterized by a deficiency in Willebrand factor, a protein that plays a crucial role in primary hemostasis and, indirectly, in coagulation. Transmitted autosomally, this disease affects both men and women, most often dominantly. It presents in various clinical forms, ranging from severe to mild, or even asymptomatic. Diagnosis is based on the results of hemostasis tests. An initial assessment, generally orientative, must be supplemented by more specialized examinations in case of doubt. Once the diagnosis has been established and confirmed, characterizing the type of Willebrand disease becomes crucial, as it guides the choice of therapeutic interventions.
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