World Journal of
Pharmaceutical and Life Sciences

FORMULATION, DEVELOPMENT AND EVALUATION OF CHAMOMILE EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR GOUT

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

ABSTRACT

Chamomile has long been used in traditional medicine for the treatment of inflammation-related disorders. Gout is an inflammatory arthritis that belongs to a group of arthropathies called the ?crystalline arthropathies‘. Gout is caused by a robust inflammatory response to uric acid crystals which occurs in the setting of hyperuricemia (high uric acid levels in the blood). Supersaturation of uric acid can lead to crystal accumulation and deposition in the joints and tissues to which the immune system reacts. Uric acid tophi (which occur in tophaceous gout) appear as hard nodules under the skin and can cause considerable destruction and discomfort. Chamomile is widely used throughout the world. Its primary uses are as a sedative, anxiolytic and antispasmodic, and as a treatment for mild skin irritation and inflammation. Chamomile’s main active constituents are chamazulene, apigenin, and bisabolol. It was concluded that among the all formulations of Chamomile extract capsules the F3 was found to be as an optimized capsules according to drug release percentage 94% within 60 minutes, so the F3 was the best formulation of Chamomile extract capsules delivery system as an advanced phytotherapy approach for gout.

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