World Journal of
Pharmaceutical and Life Sciences

UNCOVERING THE LINK: CYPERMETHRIN-INDUCED HYPOTHYROIDISM, A GROWING CONCERN

Surbhi Chourasiya* and Versha Sharma

ABSTRACT

Objective: Cypermethrin (CYP) is a commonly used type II Pyrethroid. This pesticide tends to accumulate in the various body tissues, causing organ dysfunction. It is the major endocrine disrupter worldwide. The current study is primarily focused on investigating CYP-induced hypothyroidism in female mice, which is a growing concern for us. Method: The animals were divided into two groups, each comprising six mice. Group I (CN) served as a control, and Group II (CYP) was orally exposed to CYP at 15 mg/kg for 28 days. At the end, serum levels of triiodothyronine (T3), thyroxin(T4), free T3, T4, thyroid-stimulating hormone (TSH) were measured and histological study were observed. Result: The thyroid tissue was studied, which revealed that CYP leads to a marked elevation in TSH and a considerable decline in fT3, fT4, T3, and T4 levels. Moreover, a significant increase in the biomorphometric indices body weight and a substantial decrease in thyroid weight were seen. Marked morphometric abnormalities and hormonal dysregulation indicated the CYP-induced hypothyroidism condition. The results revealed abnormal thyroid histomorphometry in the CYP-induced hypothyroidism group. Conclusion: These results suggest CYP-induced hypothyroidism in female mice. This work suggests that the consumption of CYP is a growing concern because it is proven that it can cause hypothyroidism in mice.

[Full Text Article]   [Download Certificate]