World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON PERSONALIZED MEDICINE IN CANCER TREATMENT BASED ON GENETIC PROFILING

Shubamalya L. G.*, S. B. Nirmita, Uttarker Kalyan, Melba A., Krishna K. S. and Lakshana K.

ABSTRACT

With the individualization of treatment through patterns of genetic profiling, personalized medicine is altering cancer treatment enabling the creation of individualized therapies as per what has been detected to be unique concerning the patient in terms of genetics. Genetic profiling provides evidence for certain mutations, for losses or amplifications of genes, and for particular molecular markers in the tumor, and selects the most appropriate therapies. NGS, liquid biopsy, and bioinformatics are the innovations most embedded into the practice, as they also provide deeper understanding into tumor biology and how such tumors respond to treatment. The role of genetic profiling in personalized cancer therapy is weighed up in this review, addressing how it may be applied to target selection for therapies, immunotherapies, and chemotherapy regimens. Also discussed are the benefits on the clinical side, including increased rates of survival, fewer side effects, and improved quality of life for patients. However, some limitations to widespread use exist: expensive genetic testing, limited treatment access, and the inherent complexity with which genetic data are interpreted. The future of personalized medicine in cancer lies in multi-omics technologies, artificial intelligence, and improving accessibility because these elements combined can further revolutionize cancer care and emphasizes outcomes.

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