Abstract
RESEARCH ARTICLE ON CARRY OUT PHARMACOLOGICAL EVALUATION OF AZADIRACHTA INDICA AGAINST ISONIAZID RIFAMPICIN INDUCED HEPATOTOXICITY IN LABORATORY RAT
Miss. Madhuri Ramchandra Pawar*, Miss. Shital Subhash Khandagale, Mr. Nilesh Sopana Kothare and Dr. Hemant Kamble
ABSTRACT
Two essential medications for the treatment of tuberculosis, isoniazid (INH) and rifampicin (RIF), are linked to hepatotoxicity, which presents serious clinical difficulties. In this work, laboratory rats' hepatoprotective responses to INH-RIF-induced hepatotoxicity are assessed using Azadirachta indica, or neem. INH-RIF was administered to cause liver damage as part of the experiment, and Azadirachta indica extract was then used as a therapy. In addition to histological analysis of liver tissues, biochemical indicators of liver function such as serum ALT, AST, ALP, and total bilirubin were measured. The findings showed that by restoring histological architecture and normalizing biochemical indicators, Azadirachta indica considerably reduces liver damage. The results imply that Azadirachta indica has hepatoprotective qualities, which may be facilitated by its anti-inflammatory and antioxidant effects. This study highlights the therapeutic potential of Azadirachta indica as a complementary strategy in managing drug-induced hepatotoxicity.
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