World Journal of
Pharmaceutical and Life Sciences

MICROBIOME PHARMACOLOGY AND THE GUT-BRAIN AXIS IN DISEASE MANAGEMENT

Gazal Rani* and Dr. Vikas Gupta

ABSTRACT

The human microbiome, which consists of trillions of microorganisms, plays a critical role in maintaining health by influencing various bodily functions, including metabolism, immune responses, and brain activity. Emerging research underscores the importance of the microbiome in the gut-brain axis, a complex communication system that connects the digestive tract and the brain. Disruptions in this system, commonly referred to as "microbiome dysbiosis," have been linked to a range of conditions, including gastrointestinal disorders, neurodegenerative diseases, and mental health issues such as depression and anxiety. This review examines the pharmacological implications of the microbiome in disease treatment, with an emphasis on the gut-brain axis, and explores potential therapeutic strategies that target microbiome modulation to manage these conditions.

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