World Journal of
Pharmaceutical and Life Sciences

EVALUATION DES EFFETS DU CHLORYDRATE DE TRAMADOL SUR LES PARAMETRES HEMATOLOGIQUES ET BIOCHIMIQUES CHEZ LA SOURIS BALB/C

Lekana C.*, Miguel L. M., Dobhat-Doukakini C. R., Mbemba-bahaboula D. M., Mboungou- Malonga A. M. E., Mokondjomobé, Moukassa D. and Abena A. A.

ABSTRACT

Tramadol, an opioid analgesic, is widely used for treating moderate to severe pain. Although it has a relatively favorable safety profile, it can cause various side effects, particularly affecting hematological and biochemical parameters. This preclinical study evaluated the impact of tramadol hydrochloride on these parameters in BALB/C mice by measuring hematological (red blood cell count, hemoglobin levels, hematocrit) and biochemical (blood glucose, creatinine, urea, ASAT, ALAT) markers. The mice were divided into three groups: a control group treated with distilled water, and two groups treated with 20 mg/kg and 40 mg/kg of tramadol, administered over 49 days. The results showed significant weight loss in the tramadol-treated groups, especially at the 40 mg/kg dose. Hematological analysis revealed a decrease in red blood cell count, hemoglobin levels, and hematocrit, particularly in the high-dose group, suggesting an anemic effect. Biochemical analyses showed significant alterations in metabolic and organ markers. Blood glucose levels significantly decreased, and signs of nephrotoxicity and hepatotoxicity were observed, with increased creatinine, urea, ASAT, and ALAT levels. These effects were more pronounced at the 40 mg/kg dose, highlighting the potential risks of high-dose tramadol use. These findings suggest that tramadol can induce significant adverse effects on hematological, renal, and hepatic systems, emphasizing the need for careful monitoring during long-term use.

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