World Journal of
Pharmaceutical and Life Sciences

PHYTOCHEMICAL COMPOSITION AND PHARMACOLOGICAL APPLICATIONS OF HERBAL PLANTS: A COMPREHENSIVE EXPLORATION OF THEIR ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT PROPERTIES IN BONE CANCER

Geetha Balasubramani*, Prince Wilfred J. and Paul Pradeep J.

ABSTRACT

Bone cancer presents a significant therapeutic challenge in oncology, requiring new, effective treatment strategies. Phytotherapy offers potential alternatives due to its bioactive compounds that may reduce side effects compared to conventional cancer treatments. This review compares the phytochemical profiles, anti-cancer, and anti-inflammatory properties of three medicinal plants: Blepharis maderaspatensis (Elumpu Otti), Centella asiatica (Vallarai), and Calotropis procera (Vellarukku), to explore their efficacy against bone cancer. A comprehensive analysis of the in vitro and in vivo effects of these plants on cancer cells was conducted, focusing on their mechanisms of action, such as apoptosis induction and angiogenesis inhibition. The review also evaluates the synergistic potential of combining these herbs with conventional therapies. The review demonstrates that Blepharis maderaspatensis, Centella asiatica, and Calotropis procera possess significant anti-cancer and anti-inflammatory properties. They exhibit mechanisms such as inducing apoptosis and inhibiting angiogenesis in cancer cells, suggesting their potential in bone cancer treatment with minimal toxicity. The findings indicate that these plants offer promising complementary options for bone cancer therapy. Their bioactive compounds could provide safer, effective alternatives or adjuncts to conventional treatments, warranting further in-depth research into their synergistic effects.

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