Abstract
ANALYZING THE SATURATED SOLUBILITY OF RABEPRAZOLE SODIUM IN DIFFERENT DISSOLUTION MEDIA VIA UV/VISIBLE SPECTROPHOTOMETER
Chidananda B. N.*, J. Adlin Jino Nesalin, E. Gopinath, Ganesh N. S. and Vineeth Chandy
ABSTRACT
Solubility is a fundamental pre-formulation factor that significantly influences the formulation and development of
drugs. It plays a crucial role in determining the bioavailability of solid dosage forms, such as tablets and capsules.
For these forms to be effective, it is essential that drug molecules are adequately solubilized. This solubilization
becomes even more important in the context of innovative drug formulations that aim to enhance therapeutic
efficacy. In this study, the focus was on assessing the solubility of Rabeprazole sodium at varying pH levels. To
achieve this, a UV-visible spectrophotometer was utilized to measure the drug's solubility in both pure water and
buffer solutions, which had pH values ranging from 1.2 to 7.4. This method allowed for a precise evaluation of
how different pH environments would influence the solubility characteristics of Rabeprazole sodium. The results
clearly indicated that the solubility of Rabeprazole sodium is pH-dependent, which means that changes in the pH of
the dissolution medium can significantly affect the solubility of the drug. This finding is particularly relevant for
formulators, as it highlights the need to consider pH when developing tablets and capsules. By optimizing the
solubility conditions, formulators can improve the bioavailability and therapeutic effectiveness of Rabeprazole
sodium, ultimately leading to more successful treatment outcomes. Understanding these solubility dynamics is
essential in the quest for effective pharmaceutical formulations.
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