World Journal of
Pharmaceutical and Life Sciences

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF SOME NOVEL PYRIMIDINE- BASED CHALCONE DERIVATIVES

Lirin Mary M. K.*, Nipu Sam P. George, Akhila S. Dileep and Harsha S.

ABSTRACT

The synthesis and analysis of chalcone and its derivatives are vital in organic chemistry due to their wide-ranging biological activities. Chalcones, characterized as α, β-unsaturated carbonyl compounds, serve as essential intermediates in the formation of various heterocyclic compounds like flavonoids and isoflavonoids. This study involves synthesizing chalcone through the Claisen-Schmidt condensation reaction between acetophenone and m- chlorobenzaldehyde, and subsequently developing a pyrimidine derivative using urea and sodium ethoxide. The reaction progress was tracked with Thin Layer Chromatography (TLC), and the final compounds were characterized using UV, IR, NMR, and GC-MS techniques. The study's objective was to assess the biological properties of these chalcone derivatives, with a focus on their antibacterial activity. The results revealed that the synthesized pyrimidine derivative exhibited notable antibacterial effects against *Escherichia coli*, highlighting its potential for pharmaceutical applications.

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