World Journal of
Pharmaceutical and Life Sciences

MITIGATION OF FLUORIDE INDUCED LIPID PEROXIDATION AND GASTROINTESTINAL BIOCHEMISTRY DYSFUNCTION IN RAT BY BOERHAAVIA DIFFUSA L.

Shashi A.* and Sukhmanjeet Kaur

ABSTRACT

The present study evaluated the toxic effects of oral administration of sodium fluoride on oxidative stress parameters and its possible amelioration upon treatment with leaf extract of Boerhaavia diffusa L. in Wistar albino rats divided randomly into six groups with six rats in each. Group 1 served as control (C1) receiving deionized water. Group II was orally administered with 600 mg/kg b.w./day of sodium fluoride for 40 days. Group III (C2) and Group IV (C3) were administered with 250 and 500 mg/kg b.w./day of Boerhaavia diffusa L. for 20 days respectively. Group V and Group VI were firstly exposed to 600 mg of NaF and then post-treated with 250 and 500 mg of leaf extract for 20 days. The level of malondialdehyde (MDA) exhibited a significant (P< 0.001) increase, while alterations in reduced glutathione (GSH) and activities of superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) revealed a significant (P<0.001) decline in all organs viz; stomach, duodenum, jejunum and ileum of fluoridated rats. However, after mitigation with leaf extract in NaF treated rats manifested a significant decrement (P<0.001) in the activity of antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase. There was significant improvement with leaf extract of Boerhaavia diffusa L. on devastating effects of NaF in stomach and small intestine of fluoridated rats.

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