World Journal of
Pharmaceutical and Life Sciences

DESIGN, SYNTHESIS, MOLECULAR DOCKING & IN VITRO ANTIOXIDANT EVALUATION OF ISONIAZID DERIVATIVES

Devika Chandran, Harsha S., Vaishak S. and Lirin Mary M. K.*

ABSTRACT

This research focuses on the synthesis and analysis of Isoniazid derivatives, emphasizing their potential antioxidant properties in addition to their established antimicrobial effects. The process began with the oxidation of 4-
methylpyridine to create Isonicotinic acid, which was then reacted with anhydrous hydrazine to produce Isoniazid.
Various derivatives were formed by reacting Isoniazid with different aldehydes. These compounds were analyzed
using techniques such as Thin Layer Chromatography, UV and IR spectroscopy, and mass spectrometry. Docking
studies were performed to evaluate their binding affinity with cytochrome C peroxidase, and their antioxidant
activities were assessed using the DPPH radical scavenging assay. The findings revealed that while all derivatives
demonstrated some antioxidant activity, compound 1(a) had the highest inhibition percentage. Nonetheless, their
effectiveness was lower than that of the standard antioxidant, Ascorbic acid, indicating that further improvements
are needed.

[Full Text Article]   [Download Certificate]