World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PREPARATION AND EVALUATION OF NANOPARTICLE GEL USED IN PSORIASIS TREATMENT

Siddiqua Habeeb*, Md. Hamza Habeeb and Bhargav Bhongiri

ABSTRACT

The objective of the present study is to formulate and evaluate Nano particulate gel containing methotrexate. It is used in the treatment of psoriasis. Methotrexate nanoparticles were formulated by the nanoprecipitation technique and evaluated for particle size, drug entrapment efficiency, SEM analysis, and FTIR studies. Optimized formulation of methotrexate nanoparticles further converted into the gel using Carbopol 934. Methotrexate loaded nanoparticles showed a spherical shape with smooth surface. In vitro anti-psoriatic study suggested that the developed methotrexate Nano particulate gel formulation exhibits improved dermal delivery of methotrexate and also nanoparticles had a superior effect on cell growth as compared to the free methotrexate. Pharmacokinetic study established that the amount of methotrexate reaching the viable layer is slightly high for Nano particulate gel as compared to free methotrexate. Thus, methotrexate loaded Nano particulate gel formulation might be the potential delivery system for the treatment of psoriasis.

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