Abstract
FORMULATION AND EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETS USING AEGLE MARMELOS GUM
Bhogireddi Sri Swetha*, Birudugadda Bhanu, Gali Venkata Prazna, Kotta Kavya Sri Udaya Lakshmi, Peddiboyina Sravani Durga and Tirumani Kanaka Durga
ABSTRACT
The present study is to investigates the effect of acacia gum with drug of diclofenac sodium tablets. Acacia gum is used as synthetic polymer It was characterized for physicochemical properties like solubility, loss on drying, ash content, angle of repose, density, compressibility index etc. Diclofenac sodium matrix tablets were prepared by wet granulation with four formulations (AM-1 to AM-4) containing 100 mg drug and gum in different ratios (1:0.25 to 1:2). Tablets were evaluated for properties like thickness, hardness, friability, drug content, disintegration time. Drug release was studied in 0.1N HCl for 2 hrs and phosphate buffer pH 7.4 for 10 hrs using USP Type II dissolution apparatus. Among the formulations, AM-4 with drug:gum ratio of 1:2 showed slowest drug release of 98.86% over 12 hrs. The results indicate that acacia gum is suitable for use as a release retardant in diclofenac sodium sustained release matrix tablets.. The prepared formulations were evaluated for pre-compression parameters relevant to granules like angle of repose, bulk density, tapped density, hausner’s index and carr’s index while tablets were evaluated for various post-compression parameters like tablet thickness, hardness, weight variation, friability, content uniformity, disintegration time, swelling behaviour and in-vitro drug release study.
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