World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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M. S. Vijayalakshmi, T. Yasodha* and K. Kiruthiga


Piperidine-4-one was synthesized by the condensing hexane-2-one, 4-fluoro benzaldehydes and ammonium acetate in 1:2:1 ratio. Synthesized compound was characterized by 1H NMR spectra. In spectral studies, the observed carbonyl stretching frequency at 1715 cm-1, secondary amine stretching frequency at 3300 cm-1 and aliphatic and aromatic C-H stretching frequencies appeared at 3075-2804 cm-1 were being the supporting evidence for the formation of target compound. On the basis of chemical shift and coupling constant value, it has been confirmed that compound 3-allyl 2,6-bis(4-fluorophenyl)piperidine-4-one adopt chair confirmation with equatorial orientation of phenyl rings. Results of present study demonstrate that a new class of piperidine was synthesized and evaluated for its pharmacological study as antibacterial agent. The newly synthesized heterocyclic piperidine exhibited efficient, shorter reaction times and simple purification procedures. It is economic for the synthesis of 3-allyl 2,6-bis(4-fluorophenyl) piperidine-4-one. It was shown that the piperidine rings of compound adopt chair confirmations. Analytical and spectral data of 3-allyl 2,6-bis(4-fluorophenyl) piperidine-4-one revealed a new horizon towards the pharmacological actions against the bacterial pathogens of hospital environment. The promising effect of synthetic piperidine from 2mg/ml to 5mg/ml concentrations against bacterial pathogens of hospital effluents was evident from the results of three different sites. There was no activity less than 1 mg/ml. Moderate activity was observed from 1.2mg/ml to 2mg/ml.Hence it can be concluded that this synthetic piperidine at concentrations from 3mg/ml to 5mg /ml certainly holds great potential towards good active compound leads in antimicrobal study.

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