World Journal of
Pharmaceutical and Life Sciences

CARISSA SPINARUM: A POTENT RENOPROTECTIVE AGENT AGAINST ALLOXAN INDUCED DIABETES

Arti Rana* and Sushma Sharma

ABSTRACT

Carissa spinarum also known as ‘‘conkerberry’’ or ‘‘Bush Plum’’ is a large shrub, which belongs to the family of Apocyanaceae. This species is widely distributed in tropical region and in India. A chemical study of this plant led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds have been evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. Present study was aimed to study effects of Carissa spinarum methanolic leaf extract in alloxan treated mice pancreas. Mice were injected with alloxan monohydrate (150 mg/kg BW) intraperitoneally and selected diabetic mice were divided into four groups with six mice in each group. Diabetic mice were given Carissa leaf extract orally to a dose of 600 and 800 mg/kg body weight and glimepiride (2mg/kg body weight) for 28 days daily. The histopathological studies of kidney of diabetic mice revealed degeneration of renal architecture, but after supplementation of Carissa spinarum leaf extract reformative changes were observed. Significant changes in serum urea, creatinine, enzyme activities of SOD, CAT, GPx, glutathione levels and lipid peroxidation levels were recorded after extract administration to alloxan induced oxidative stress in diabetic mice.

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