World Journal of
Pharmaceutical and Life Sciences

PHYTOCHEMICAL SORTING AND BIOTOLERANCE OF AN IMPROVED TRADITIONAL MEDICINE USED IN THE TREATMENT OF HEPATITIS B IN CÔTE D’IVOIRE

Mariam Kone1, Abba P. Obouayeba*, Bognan Jacques A. A. Ackah and Kassim Dosso

ABSTRACT

The use of plants for therapeutic purposes is very old. Even today, they are used by a fraction of the world's
population. This work focused on the phytochemical sorting and the evaluation of the acute toxicity of an Ivorian
phytomedicine "ABRAHAM" used in the treatment of hepatitis B, in Wistar albino rats. To do this, the
phytomedicine ABRAHAM was administered, in a single dose, orally to four groups of rats, at doses of 500, 1000,
2000 and 5000 mg/kg of body weight. The animals were observed for 14 days. Subsequently, the main chemical
compounds as well as hematological and blood biochemical parameters were studied. Phytochemical screening
revealed the presence of polyphenols, flavonoids, tannins, quinones, polyterpenes and sterols, alkaloids and
saponins. Moreover, the phytomedicine does not significantly disturb the hematological parameters consisting of
the rate of red blood cells, white blood cells, blood platelets and hemoglobin. Finally, ABRAHAM had no adverse
effect on hepatic, renal markers and serum lipid profile of treated rats.

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