Abstract
EVALUATION AND VALIDATION OF A UPLC METHOD FOR THE STABILITY INDICATING ASSAY OF MIDOSTAURIN IN BULK DOSAGE FORM
Dr. Osman Ahmed*, Khadeeja and Dr. Anas Rasheed
ABSTRACT
This proposal provides a comprehensive review of the optimization and approval of the LCMS technology for evaluating midostaurin, a chemical that potentially be a tyrosine kinase inhibitor. Analysts had to choose a permanent and movable stage, as well as develop standard stock and diluent arrangements, in order to find the best circumstances for division. The study indicated that a BDS C18 provided the best determination and affectability when combined with slope programming, using a portable stage of methanol and acetonitrile (80:20 v/v). By analyzing the method's precision, linearity, adaptability, and exactness, the panel also looked at the method's validity. Considerations of accuracy showed respectable recoveries, with a brutality level of 99.28%. There were factually irrelevant ponders of correctness that proved the system and approach were accurate.
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