World Journal of
Pharmaceutical and Life Sciences

EVALUATION AND VALIDATION OF A UPLC METHOD FOR THE ESTIMATION OF MIDOSTAURIN IN BULK DOSAGE FORM

Khadeeja*, Dr. Osman Ahmed and Dr. Anas Rasheed

ABSTRACT

Midostaurin could be a tyrosine kinase inhibitor, and this proposal gives a total examination on the optimization
and approval of the LCMS technique for analyzing this compound. To discover the most excellent conditions for
division, analysts had to prepare standard stock and diluent arrangements and select a stationary stage and portable
stage. Employing a portable stage of methanol and acetonitrile (80:20 v/v), the inquire about found that a BDS C18
given the ideal determination and affectability when coupled with slope programming. The ponder too examined
the method's legitimacy by looking at its exactness, exactness, linearity, and flexibility. Thinks about of exactness
appeared respectable recuperations, with a cruel of 99.28%. Ponders of accuracy demonstrated the system's and
method's accuracy that were factually immaterial.

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