World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

A STUDY ON CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF COMBRETUM DENSIFLORUM EXTRACTS

Sushri Sangita Rout and Sunita Bhatnagar*

ABSTRACT

Combretum densiflorum is a member of family Combretaceae grown for ornamental purpose. Solvent extracts of leaf and bark were explored for their cytotoxic and antioxidant activities. Cytotoxic activity was studied using brine shrimp assay, chloroform extract of leaf and acetone extract of bark revealed maximum activity to the tune of 98 to 100 percent suggesting the presence of some active principles in both the samples. All the other extracts showed mild to moderate activity but one common thing was the presence of dose dependent activity in all. Antioxidant activity was conducted using TLC based DPPH assay. As far as antioxidant activity is concerned a total of 13 antioxidant bands were revealed in bark samples, while 4 antioxidant bands were obtained in leaf extracts.

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