World Journal of
Pharmaceutical and Life Sciences

CAFFEINE (1,3,7-TRIMETHYLAXANTHINE) AS A MODULATOR OF LEAD BIOACUMULATION IN THE EXPERIMENTAL MUSSELS MODEL, LAMELLIDENS CORRIANUS

P. R. Mahajan*

ABSTRACT

The present study was carried out to study modulator effect of caffeine (1,3,7-Trimethylxanthine) on Lead induced alterations on freshwater mussels, Lamellidens corrianus.The Freshwater mussels, L. corrianus were exposed to chronic LC50/10 dose of Lead nitrate (6.321 ppm) for 12 days.After 12days Lead exposed mussels were allowed to cure naturally and with caffeine. The digestive glands and gills from different groups were removed and dried in the oven. The dry powders were digested in nitric acid and perchloric acid in 4:1 ratio at hot temperature till dryness. The digest was dissolved in double glass distilled water and the lead and cadmium contents were estimated by the Atomic Absorption Spectrophotometer.After 12 days of exposure, the amount of bioaccumulated lead in the digestive glands and gills was 750 to 1.230 and 489 to 894 ?gm/Kg respectively. 568 to 932 and 415 to 675 ?gm/Kg in Pb in with caffeine. During the recovery after 12 days, the bioaccumulated lead was reduced to 1.057 to 835 and 728 to 518 ?gm/Kg of normal water while in caffeine exposed mussels was reduced to 950 to 680 and 635 to 494 ?gm/Kg in digestive glands and gills respectively. Decrease in the lead contents in caffeine exposed mussels indicates the role of caffeine in lead excretion. Therefore, the caffeine (1, 3, 7-Trimethylxanthine) as a modulator of lead bioaccumulation in the experimental mussels model, L. Corrianus

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