World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Scientific Indexing Services (SIS), Indian citation Index (ICI), Directory of Research Journals Indexing, Scintific journal impact factorScientific Journal Impact Factor (SJIF), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Cosmos Impact Factor, IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Research Bible, Fuchu, Tokyo. JAPAN, Scholar Article Journal Index (SAJI), Scope Database, Academia, 



Rao Muhammad Abid Khan*, Kulsoom, Ramsha Mukhtar, Muhammad Faisal, Muhammad Yaseen, Muhammad Shaheen Iqbal


An infection can be seen as a battle between the invading pathogens and the host. Human body is equipped with natural defenses to fight off these invading pathogens. Complement system is an evolutionary conserved arm of innate immunity to handle this tug of war by several means including labeling of bacteria with opsonins, facilitating phagocytosis through chemoattractants, bacterial lysis through pore formation and production of antibodies by switching innate to adaptive immunity. However, by no means it is explicitly fool proof. Nonspecific nature, over activation, polymorphism, genetic mutations, and alteration in self-cells (i.e. cancer) may result in unwanted complement-mediated damage to self-body. On the other hand, deficiencies in complement proteins result in high risk of getting frequent infections. Furthermore, complements are essential in maintaining homeostasis by coordinating inflammation, eliminating and recycling cellular debris, and maintaining apoptosis. Vigilant regulation of complement is essential to avoid self-harm to host body. One of the strategy for regulation is most of the complement proteins are synthesized as inactive precursors and each act as a triggered protease which successively cleaves other proteins in a cascade. Another manoeuvre is the group of charismatic proteins called regulators of complement activation (RCA). A number of soluble-circulating and membrane-bound RCA have been delineated so far in the literature. In this review, we describe the three complement pathways and interplay of complements and their soluble-circulating and membrane-bound regulators in the human body.

[Full Text Article]   [Download Certificate]


  All Since 2019
 Citation  422  322
 h-index  9  7
 i10-index  4  2



    A PHP Error was encountered

    Severity: Notice

    Message: Undefined variable: news

    Filename: views/right_panel.php

    Line Number: 79

    A PHP Error was encountered

    Severity: Warning

    Message: Invalid argument supplied for foreach()

    Filename: views/right_panel.php

    Line Number: 79


World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here