World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

STUDY OF ALZHEIMER’S DISEASE ON BARK OF KYDIA CALYCINA IN HYDRO-ALCOHOLIC EXTRACT AND IN-VITRO STUDY

P. Nirmala*, Jency Abraham*, Parvathy Madhusoodhanan, Gomathi A.R. and Sushmitha C.

ABSTRACT

The present study was performed in the bark of Kydia Calycina for the study of Alzheimeric activity using hydro-alcoholic extraction in the ratio 1:1.It was aimed to carry out the in-vitro study of “Acetyl cholinesterase inhibition activity” by Ellman’s method. The present investigation was aimed to determine Alzheimer`s disease(AD) in the bark of Kydia Calycina. The report of respective study shows the dose dependent increase in percentage inhibitory activity for Anti-cholinesterase activity by Ellman’s method. From the results of the present study, it was concluded that, the bark of the plant exhibits Alzheimeric activity. The Alzherimeric activity produced by the hydro-alcoholic extract at 250 µg/ml concentration shows the percentage inhibition of Anti-cholinertase which is compared with that of same concentration of standard Ellman’s reagent.

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