World Journal of
Pharmaceutical and Life Sciences

MICROPARTICULATE DRUG DELIVERY SYSTEM-- A REVIEW

Biidyut Das and Jutii Ranii Devii*

ABSTRACT

Microparticles are small particles of solids or small droplets of liquids surrounded by walls of natural & synthetic polymer films of varying thickness & degree of permeability acting as a release rate controlling substance & have a diameter up to the range of 0.1?m-200?m. Microparticles are now one of the very widely used technique for drug delivery as it has several advantages like improved bioavailability, reduced dosage frequency, limited fluctuation during therapeutic range, low toxic effect etc. Several techniques for microparticles preparation are there among those spray drying, hot melt encapsulation, single emulsification, solvent evaporation, ionotropic gelation methods were mainly used, depending up on the type of microparticle to be prepared. Different types of microparticles that have prepared were magnetic, floating, bioadhesive, radioactive, mucoadhesive etc. One major advantage of the microparticulate drug delivery system is that by the use of either natural or synthetic rate controlling polymers it’s drug release can be controlled for long period.

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