World Journal of
Pharmaceutical and Life Sciences

CLITORIA TERNATEA FLOWER EXTRACT MAY HAVE THE POTENTIAL TO REGULATE HYPERTHYROIDISM IN MICE

Yasha Jitendra Jha* and Anand Kar

ABSTRACT

Background: Hyperthyroidism can prove to be a serious disease, if not treated properly. Although for the treatment of hyperthyroidism some conventional medicines are available, nothing has been reported with respect to the role of flower in this aspect. Objective: To investigate the anti-hyperthyroidic effect of Clitoria ternatea flower extract on experimentally induced hyperthyroid mice. Methods: First of all antioxidative potential of Clitoria ternatea flower was studied by an in vitro method using DPPH .Then in an in vivo study, L-thyroxine (L-T4) at 0.5 mg/kg/d was administered through intra-peritoneal route for 15 consecutive days to induce hyperthyroidism in which the effects of three different doses (400, 200 and 100 mg/kg body weight) of the C. ternatea flower extract for 12 days were investigated on the changes in hepatic lipid peroxidation (LPO), enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathioneperoxidase (GSH). Simultaneously alteration in serum cholesterol was evaluated. Results: In vitro DPPH assay showed the antioxidant properties of the test extract. In In-vivo study, following the administration of L-T4, serum cholesterol and the tissue LPO were increased with a decrease in anti-oxidative enzymes. However, administration of the C. ternatea flower extract to hyperthyroid animals significantly decreased the levels of hepatic LPO and normalized the serum cholesterol and glucose level along with antioxidative enzymes, suggesting it’s antihyperglycemic and antiperoxidative potential. Conclusion: These findings suggest that C. ternatea flower has the potential to correct the hyperthyroidism- induced tissue LPO and hypolipidemia.

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