World Journal of
Pharmaceutical and Life Sciences

CELL PENETRATING PEPTIDES IN PHARMACOLOGICAL ASPECT

*Sourabh Mukherjee, Dr. Sattwik Das and Dr. Beduin Mahanti

ABSTRACT

Cell-penetrating peptides and proteins (CPPs) are compounds which can penetrate live cells and can transport cargoes and labels into the cell or even into subcellular organelles. Some cells are easy to transduce or to transfect, other cells only difficult or not to transfect. CPPs are very effective in transporting peptides, proteins, hydrophilic bioactive synthetic or natural compounds. Furthermore, they are tools for transporting drugs, including herbal products from classical chine´s medicine. CPPs are also able to transport ribonucleic acids and derivatives of them like peptide nucleic acids or morpholino oligomers. CPPs are also able to penetrate barriers like blood-brain barrier, conjunctiva of eye, skin, epithelial tissue, and intestinal mucosa. As membrane-active peptides some of them can kill microorganisms directly or can transport effective antimicrobial drugs into infected cells.[1]

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