World Journal of
Pharmaceutical and Life Sciences

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF FEXOFENADINE MOUTH DISSOLVING TABLETS

Rayapati Raju, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

ABSTRACT

In the present study, attempt was made to formulate instant palatable mouth dissolving tablets of Fexofenadine. Formulation F9 revealed promising results which was formulated by Crosspovidone in 5:4 ratio. This formulation exhibited highest water absorption and hydration capacity, showed least disintegrate time and highest percent drug release which provides quick onset of action and immediate relief in suddenly arising allergic reactions. Moreover, they showed pleasant mouth feel. This formulation satisfied all the tablet evaluation parameters for Mouth Dissolving Drug Delivery System. Hence, it was concluded that the F9 Formulation is optimized formulation amongst F1 to F9. Optimized Formulation F9 was tested for Accelerated stability as per ICH guidelines was found to be a stable at 40oC ± 2oC temperature and 75% ± 5% relative humidity for three months. Undoubtedly Fexofenadine MDT will surely give the rapid onset of action, quick relief, low side effects, pleasant mouth feel, good stability, improved patient compliance, and its popularity in the near future.

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