World Journal of
Pharmaceutical and Life Sciences

EXPERIMENTAL STUDIES TO STUDY THE SPECIFIC ACTIVITY OF THE CHOLERETIC COLLECTION

*Dr. Mamatkulov Z. U. (PhD), Prof. Dr. Rizaev K. S., Prof. Dr. Tulaganov R. T. and Dr. Tillaeva U. M. (DSc)

ABSTRACT

The risk of chronic diseases of the biliary tract is increasing, and in developed countries this is given special attention. Of particular interest are choleretic herbal medicines in the domestic market. It is noted that the need for them is increasing. This study is devoted to the definition of the main groups of biologically active substances of the developed compositions of multicomponent collections obtained from local plant materials. The specific activity of the tested preparations "Stigmachole" was studied. The experiments were carried out on white mice weighing 18-20 g of both sexes. The data obtained were statistically processed using the STATISTICA program. The study comparators were administered intragastrically at a dose of 10 ml/kg. The mice were decapitated under light anesthesia, the livers were exposed, and the bile ducts were ligated. The gallbladder was dissected from the bile ducts and weighed after bile removal. The mass of bile in the gallbladders of experimental and control mice was determined by the difference in mass. According to the results of the experiment it was found that with the introduction of an infusion of choleretic collection No. 3, it increased the mass of bile by 4.48 times compared with the control group, i.e. has a pronounced choleretic activity and is recommended for further study as a choleretic agent. The results show the prospect of creating new choleretic agents based on local plant materials and introducing them into domestic pharmacy.

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