Abstract
DEVELOPMENT AND EVALUTION OF FLOATING MICROSPHERES OF OMEPRAZOLE
*Priyanshi Chauhan, Kapil Kumar, Ikram, Aparna Joshi, Deepti Khairya and Deepak Teotia
ABSTRACT
The gastro retentive system prolongs the drug's gastric retention time through staying for many hrs in GIT region. The main aim of the present investigation is to formulate Omeprazole loaded Floating microspheres by spray drying technique. The obtained formulations were evaluated for drug content, entrapment efficiency, Buoyancy time and in vitro dissolution studies. The entrapment efficiency was found to be increased by increasing the concentration of the polymer. In vitro dissolution studies were conducted for a period of 12 hours. The drug release was continued up to 12 hrs with 99% drug release. From the study it was concluded that formulation with code F4 was yielding the best floating microspheres which were floating for a period of 24 hrs. It decreases drug waste while enhancing the bioavailability and solubility of the medication. These systems possess low density thus remain buoyant for longer time.
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