World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF LIMONIA ACIDISSIMA LEAF EXTRACT IN REDUCING OXIDATIVE STRESS AND NEURODEGENERATION IN SCOPOLAMINE-INDUCED ANIMAL MODEL OF ALZHEIMERS DISEASE

Syeda Madiha Maheen, Faizan Hussaini*, Syed Muneb Ahmed, Shaik Ibadullah, Syed Jaffer and Anupama Koneru

ABSTRACT

The present study was designed to evaluate limonia acidissima leaf extract in reducing oxidative stress and neurodegeneration in scopolamine-induced animal models of Alzheimer’s disease. The extraction was carried out with an aqueous extract of Limonia acidissima leaves. The preliminary phytochemical screening showed the presence of glycosides flavonoids, tannins, phenolics, phytosterol, and saponins. This activity was evaluated by using the mice behavioral model i.e. T-maze performance and Elevated maze performance for 15 days, with an estimation of neurotransmitters in animals’ brains. An individual animal was administered with 250mg/kg, 750mg/kg 2000mg/kg body weight dose one at a time orally. The animal was observed for 24 hours, the animal survived. Histology of hippocampal neurons in the case of control groups of Limonia acidissima and Donepezil showed almost normal hippocampal cells when compared with their corresponding scopolamine treated group. The present study reveals that an aqueous preparation of Limonia acidissima has a significant role in the management of cognitive impairment and oxidative stress.

[Full Text Article]   [Download Certificate]