World Journal of
Pharmaceutical and Life Sciences

MINI REVIEW ON NASAL – TO – BRAIN DRUG DELIVERY

Vasudev Jitendra Sharma*, Mayur Gokul Jayswal, Adnan Siddiqui, Aaquid Shaikh, Dr. Rehan Deshmukh and Dr. G. J. Khan

ABSTRACT

There are different type of dosage form which are administered orally, by parenteral, by topical etc. But the patient having trouble in swallowing tablets are preferred to parenteral injection. Thus, alternate to parenteral nasal drug delivery was developed. This drug delivery system is used to produced high concentration. The nasal drug delivery system has many dis advantages such as stability, physiochemical properties Blood brain barrier (this barrier restricts the transport of potential moieties to the brain), increases drug uptake, need to improve bioavailability. Nasal drug delivery system is used for both local and systemic circulation. In last five decades nasal to brain drug delivery system has gain numerous progresses, and development with numerous advantages. In this system there is direct targeting to brain via olfactory and trigeminal pathway, and gives wide range of neurotherapeutics to brain. The nasal route of administration directly delivers the drug to brain without systemic drug absorption This review is based on nasal drug delivery system, structure and function of the nose, novel drug delivery system, as nanoparticle, liposomes etc.

[Full Text Article]   [Download Certificate]