World Journal of
Pharmaceutical and Life Sciences

PRELIMINARY PHYTOCHEMICAL ANALYSIS, IN VITRO ANTIOXIDANT, AND ANTI-DIABETIC ACTIVITY OF ALOCASIA SANDERIANA METHANOLIC LEAF EXTRACT

N. Gajendran, R. Manikandan and G. Anburaj*

ABSTRACT

Objective: Alocasia santeriana W. The species has been reported to be used in the treatment of anti-diabetic in traditional/folk medicine, which may be explored for its anti-diabetic potential. Methods: A preliminary qualitative phytochemical screening of the methanol extract of Alocasia sanderiana was performed to detect alkaloids, phenolic compounds, flavonoids, saponins, tannins, glycosides, steroids, carbohydrates and various phytochemical constituents. The UV-Vis profile revealed various absorption bands ranging from 200 to 750 nm, indicating the presence of flavonoids, phenolic compounds, tannins, terpenoids, carotenoids, chlorophyll and alkaloids. 1,1- Diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging, Fe3+–Fe2+ transformation assay, ferric reducing antioxidant power (FRAP) assay, superoxide radical ion (O2•?), scavenging, radical, hydroxyls, hydroxylation, etc. Principles, nitric oxide (NO) scavenging, metal chelating and reducing power function. These various antioxidant activities were compared with standard antioxidants such as L-ascorbic acid. Results Alocasia sanderiana leaf extract exhibited the greatest antioxidant activity via DPPH, superoxide anion scavenging, metal chelator (iron chelator and iron reducing power) and nitric oxide scavenging activity. The antioxidant activity of Alocasia sanderiana is due to the presence of flavonoids and polyphenols in the extract. A.Santeriana as determined by experimental methods. The ?-amylase inhibitory activity and ?-glucosidase inhibitory activity methods were used to evaluate the anti-diabetic potential.

[Full Text Article]   [Download Certificate]