World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IMPACT OF MATRIX TABLETS AS A SUSTAINED RELEASE TABLET IN NOVEL DRUG DELIVERY SYSTEM: A REVIEW

Hans Raj*, Kapil Kumar Verma and Panshul Sharma

ABSTRACT

The goal of the Novel Drug Delivery System is to deliver a therapeutic amount of drug to the appropriate site in the body quickly and then maintain the desired drug concentration. For drugs to reach their intended target with minimal or no side effects. To reduce drug degradation and loss. Over the last decade, there has been a lot of interest in replacing traditional drug administration with a delivery system that would release effective quantities from a protected supply at a controlled rate over a long period of time. Sustained drug release formulations are extremely beneficial in the treatment of chronic diseases. Matrix tablets have been the most common forms of sustained drug release forms administered orally. Matrix tablets work by maintaining a constant plasma drug concentration, sustaining the rate of drug release over time, and producing therapeutic action for an extended period of time. Extended release is important in formulations with a short half-life and a high dosing frequency. The matrix regulates the drug's rate of release. Fire retardants such as hydroxy propyl methyl cellulose (HPMC), polyglycolic acid, and poly methyl methacrylate are employed. The drug is embedded in the retardant's matrix core. The matrices used may be hydrophobic, biodegradable, or mineral in nature.

[Full Text Article]

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