World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), Scope Database, 

Abstract

REVIEW ON VANISHING WHITE MATTER DISEASE

*Varsha V. Bolar, Grinton Josvi Veigas, Dr. Noah Mani Bose, Ramdas Bhat and Dr. Ravi Kumar Nayak

ABSTRACT

Vanishing white matter (VWM) disease is a type of disorder which mainly affects the brain and spinal cord. This disorder mainly causes deterioration of white matters in Central nervous system specifically the nerve fibres covered with myelin. The basic defect of the disease is caused by mutations in one of the five genes eIF2B1, eIF2B2, eIF2B3, eIF2B4 and eIF2B5 that encodes the five subunits of a protein called eukaryotic translation initiation factor (eIF2B), which is essential for the protein synthesis and regulations in all cells of the body under different stress conditions. VWM disease is characterised by chronic progressive and episodic worsening with ataxia (loss of control of body movements), spasticity (abnormal muscle tightness) and optic atrophy (worsening of vision). This disease is diagnosed on the basis of clinical symptoms in amalgamation with the results of a Magnetic Resonance Imaging (MRI) scan of the brain which shows distinctive pattern of abnormalities in the white matter of the brain.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here