World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PHYTOCHEMICAL ANALYSIS AND IN VITRO EVALUATION OF ANTIOXIDANT AND ANTICOAGULANT ACTIVITIES OF LIPPIA MULTIFLORA MOLDENKE LEAVES

Landry Martial Miguel*, Ortalie Jeancine Ouboura Moussavou, Choupette Ravelle Dobhat-Doukakini, Childérick Lékana, Archange Michel Emmanuel Mboungou Malonga, Didier Gesril Njilo Tchatchouang, Ruphin Bertrand Bolanga, Etienne Mokon

ABSTRACT

Objective: This study aimed to evaluate the phytochemical composition and in vitro antioxidant and anticoagulant properties of Lippia multiflora Moldenke leaves. Methods: Decoction and ethanol extract of leaves of L. multiflora were tested for their chemical composition, radical scavenging activity using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and spectrophotometry methods, and anticoagulant activities (estimated by PT, APTT and fibrinogen values). Results: The phytochemical screening result showed that L. multiflora leaves contain alkaloids, tannins, flavonoids, and reducing sugars. All preparations have free-radical scavenging activities. Spectrophotometry analysis results showed that the lowest IC50 value was F3 ethanol fraction, with an IC50 value of 1.83 ?g/ml ppm. The highest IC50 value was the F1 fraction, at 22.32 ?g/ml ppm. All extracts caused an increase in TP, APTT, and a decrease in fibrinogen. Conclusion: All extracts of L. multiflora leaves possess considerable antioxidant activity and are rich in total polyphenols and flavonoids. They also act in the process of coagulation. This study shows that L. multiflora leaves may have the potential to be developed as a medicinal drug.

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